NFSC 440 - Advanced Human Nutrition
This syllabus covers the general subject matter and format for the course but does not apply to any specific semester. For information about this course for a particular semester please contact the course Instructor. Syllabi for all courses in the Department of Nutrition and Food Science are subject to change at any time per decision of the Instructor. The Instructor for the course may also change at the discretion of the Department of Nutrition and Food Science.
Prerequisites
NFSC 100 or 200, BCHM 462, BSCI 440
Course Description
This course is a lecture course designed to acquaint the students with current knowledge of the physiology and biochemistry of nutrients and thorough understanding of nutrient homeostasis.
Student Achievement Objectives
- The student will know the functions of the gastrointestinal tract in digestion and absorption of nutrients.
- The student will learn the principals of energy metabolism.
- The student will understand carbohydrate, lipid and protein metabolism and factors influencing their metabolism.
- The student will be aware of the hormonal control of nutrient metabolism.
- The student will know the importance of vitamins and minerals in health and disease, their interrelationships and factors influencing their metabolism.
- The student will become familiar with the metabolic basis of nutrient deficiencies and of inherited diseases which affect nutrient metabolism.
- The student will be aware of drug-induced nutritional deficiencies.
Helpful Texts (Not Required)
- Modern Nutrition in Health and Disease; Shils, Olson, Shike & Ross; 9th Ed. Williams and Wilkens; 1999.
- Recommended Dietary Allowances; National Academy Press; 10th Ed.
- Advanced Nutrition and Human Metabolism, Groff and Gropper; 3rd Ed. Wadsworth, 2000.
Instructor
David K.Y. Lei, Ph.D., Professor
0112 Skinner Bldg.
(301) 405-2143
dlei@umd.edu
Schedule of Classes
| Week # |
Topic |
| Week 1 |
Introduction and Gastrointestinal Tract
Digestion and Absorption of Lipids |
| Week 2 |
Synthesis and Degradation of Lipids
Cholesterol and Lipoprotein Metabolism |
| Week 3 |
Regulation of Lipid Metabolism
Carbohydrate Digestion and Absorption |
| Week 4 |
EXAM I
Carbohydrate Metabolism |
| Week 5 |
Protein Digestion, Absorption and Metabolism
|
| Week 6 |
Energy and Fiber
Vitamin B1 and Vitamin B2 |
| Week 7 |
Niacin, Pantothenic Acid and Vitamin B6
EXAM II |
| Week 8 |
Vitamin B12 and Folate
Vitamin C |
| Week 9 |
Vitamin A
Vitamin D |
| Week 10 |
Vitamin E and Vitamin K
Ca/P/Mg |
| Week 11 |
EXAM III
Fe |
| Week 12 |
Zn/Mn
PRESENTATIONS |
| Week 13 |
PRESENTATIONS |
| Week 14 |
PRESENTATIONS |
| Week 15 |
PRESENTATIONS
EXAM IV (FINAL) |
The written report is due 7 days before your presentation date and may be submitted earlier. Grading and Evaluation
Required Exams & Papers
| 4 Exams |
20 points per exam |
| 1 Assignment |
20 points |
| A Total of |
100 points |
A = 100-90;
B = 89.9-80;
C = 79.9-70;
D = 69.9-60;
F < 60
For each exam, the number of points needed to make the highest grade equal to the perfect score will be added to each student's test score. No extra points will be added to the paper. EXAMPLE: The first exam consisted of 50 questions; the highest grade was 44 correct answers; the test score for each student was increased by 6 correct answers [eg, (44 + 6) x 2 = 100% of 20 points].
Assignment For NFSC 440 (20 Points)
I. One written report turned in to Dr. Lei no later than 7 days before the oral presentation. The report should range from 5-6 pages, double spaced, and contain references.
II. One oral presentation of 10 to 12 minutes duration on the same topic as the written report.
III. Topics for the written report and oral presentation will be assigned from the following:
- RDA and DRI Definition and Applications
- Estimated Energy Allowance (RDA)
- RDA for Protein and Amino Acid
- RDA for Essential fatty acids
- RDA for Vitamin A
- RDA and DRI for Vitamin D
- RDA for Vitamin E
- RDA for Vitamin C
- RDA and DRI for Thiamin
- RDA and DRI for Riboflavin
- RDA and DRI for Niacin
- RDA and DRI for Vitamin B6
- RDA and DRI for Folacin
- RDA and DRI for Vitamin B12
- RDA and DRI for Calcium
- RDA and DRI for Phosphorus
- RDA and DRI for Magnesium
- RDA for Iron
- RDA for Zinc
- RDA for Iodine
- RDA for Vitamin K
- DRI for Biotin
- DRI for Panthothenic Acid
- Estimated Range for Copper
- Estimated Range for Manganese
- DRI for Fluoride
- Estimated Range for Chromium
- Estimated Ranges for Sodium, Chloride and Potassium
- RDA for Selenium
- DRI for Choline
- Estimated Range for Molybdenum
- Requirements for Copper and Zinc in Wilsons Disease
- Requirements Phenylalanine and Tyrosine in Phenylketonuria (PKU)
- Requirements for Iron and Folic acid in Sickle Cell Anemia
- Requirements for Carbohydrate in Galactosemia
IV. Unless instructed otherwise, reports and presentations should follow this outline:
- Source of nutrient
- Functions
- Symptoms of deficiency and toxicity
- Biochemical basis of symptoms
- Description of one research study (see below)
V. During the oral presentation, only briefly cover nutrient sources, functions and abnormal symptoms; spend most of the time addressing the research study (see below). Oral presentations will be graded on:
- content presented
- ability to keep within time limits
- voice is audible and clear
- sufficient number of visuals
- visuals are clear and not overly detailed (6-8 text lines/overhead)
- relevant items on visuals are pointed out to audience
- ability to answer questions.
VI. Each student should select one paper, cited in the recommended allowance section of the nutrient assigned, which supports the establishment of the RDA, DRI or estimated range. The written report and oral presentation must address the following:
- Objective(s) of the study.
- Characteristics of subjects or populations (number of subjects, sex, age, drug usage, socioeconomic background, etc.)
- Design of study (number of dietary treatments, composition of diets, duration of treatments, acclimatization and depletion/repletion periods, balance study)
- Chemical and biological assays (methods used to evaluate nutrition status, use of isotopes, use of analogs to induce deficiencies, biological samples collected)
- Transparencies or other forms of visual aid must illustrate the above 1-4, and pertinent data in tables or figures must be presented.
- A brief summary of how the current RDA, DRI or estimated range was derived from the findings of this study must be presented.
VII. The report will be reviewed by the instructor prior to the oral presentation. Part of the grade of the written report will be derived from how well you explain how the findings of the selected study contributed the establishment of the RDA/DRI/estimated range. References must be included. Format for references must be that used in the American Journal of Clinical Nutrition (See Information for Authors in AJCN).
Example:
Levy E, Rizwan Y, Thibault L, et al. Altered lipid profile, lipoprotein composition and oxidant and antioxidant status in pediatric Crohn disease. Am J Clin Nutr 2000;71:807-15.
For more information, contact Dr. David K.Y. Lei
Last updated:
10/5/2006